Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial.
Identifieur interne : 000D97 ( Main/Exploration ); précédent : 000D96; suivant : 000D98Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial.
Auteurs : Philippe Gautret [France] ; Jean-Christophe Lagier [France] ; Philippe Parola [France] ; Van Thuan Hoang [Viêt Nam] ; Line Meddeb [France] ; Morgane Mailhe [France] ; Barbara Doudier [France] ; Johan Courjon [France] ; Valérie Giordanengo [France] ; Vera Esteves Vieira [France] ; Hervé Tissot Dupont [France] ; Stéphane Honoré [France] ; Philippe Colson [France] ; Eric Chabrière [France] ; Bernard La Scola [France] ; Jean-Marc Rolain [France] ; Philippe Brouqui [France] ; Didier Raoult [France]Source :
- International journal of antimicrobial agents [ 1872-7913 ] ; 2020.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Association de médicaments (MeSH), Azithromycine (administration et posologie), Betacoronavirus (MeSH), Charge virale (MeSH), Femelle (MeSH), Humains (MeSH), Hydroxychloroquine (administration et posologie), Infections à coronavirus (traitement médicamenteux), Mâle (MeSH), Pandémies (MeSH), Pneumopathie virale (traitement médicamenteux), Réaction de polymérisation en chaîne (MeSH).
- MESH :
- administration et posologie : Azithromycine, Hydroxychloroquine.
- traitement médicamenteux : Infections à coronavirus, Pneumopathie virale.
- Adulte, Adulte d'âge moyen, Association de médicaments, Betacoronavirus, Charge virale, Femelle, Humains, Mâle, Pandémies, Réaction de polymérisation en chaîne.
English descriptors
- KwdEn :
- Adult (MeSH), Azithromycin (administration & dosage), Betacoronavirus (MeSH), Coronavirus Infections (drug therapy), Drug Therapy, Combination (MeSH), Female (MeSH), Humans (MeSH), Hydroxychloroquine (administration & dosage), Male (MeSH), Middle Aged (MeSH), Pandemics (MeSH), Pneumonia, Viral (drug therapy), Polymerase Chain Reaction (MeSH), Viral Load (MeSH).
- MESH :
- chemical , administration & dosage : Azithromycin, Hydroxychloroquine.
- drug therapy : Coronavirus Infections, Pneumonia, Viral.
- Adult, Betacoronavirus, Drug Therapy, Combination, Female, Humans, Male, Middle Aged, Pandemics, Polymerase Chain Reaction, Viral Load.
Abstract
BACKGROUND
Chloroquine and hydroxychloroquine have been found to be efficient on SARS-CoV-2, and reported to be efficient in Chinese COV-19 patients. We evaluate the effect of hydroxychloroquine on respiratory viral loads.
PATIENTS AND METHODS
French Confirmed COVID-19 patients were included in a single arm protocol from early March to March 16
RESULTS
Six patients were asymptomatic, 22 had upper respiratory tract infection symptoms and eight had lower respiratory tract infection symptoms. Twenty cases were treated in this study and showed a significant reduction of the viral carriage at D6-post inclusion compared to controls, and much lower average carrying duration than reported in the litterature for untreated patients. Azithromycin added to hydroxychloroquine was significantly more efficient for virus elimination.
CONCLUSION
Despite its small sample size, our survey shows that hydroxychloroquine treatment is significantly associated with viral load reduction/disappearance in COVID-19 patients and its effect is reinforced by azithromycin.
DOI: 10.1016/j.ijantimicag.2020.105949
PubMed: 32205204
PubMed Central: PMC7102549
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France; Thai Binh University of Medicine and Pharmacy, Thai Binh, Viet Nam.</nlm:affiliation><country xml:lang="fr">Viêt Nam</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France; Thai Binh University of Medicine and Pharmacy, Thai Binh</wicri:regionArea><wicri:noRegion>Thai Binh</wicri:noRegion></affiliation></author><author><name sortKey="Meddeb, Line" sort="Meddeb, Line" uniqKey="Meddeb L" first="Line" last="Meddeb">Line Meddeb</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Mailhe, Morgane" sort="Mailhe, Morgane" uniqKey="Mailhe M" first="Morgane" last="Mailhe">Morgane Mailhe</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Doudier, Barbara" sort="Doudier, Barbara" uniqKey="Doudier B" first="Barbara" last="Doudier">Barbara Doudier</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Courjon, Johan" sort="Courjon, Johan" uniqKey="Courjon J" first="Johan" last="Courjon">Johan Courjon</name><affiliation wicri:level="3"><nlm:affiliation>Infectiologie, Hôpital de l'Archet, Centre Hospitalier Universitaire de Nice, Nice, France; Université Côte d'Azur, Nice, France; U1065, Centre Méditerranéen de Médecine Moléculaire, C3M, Virulence Microbienne et Signalisation Inflammatoire, INSERM, Nice, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Infectiologie, Hôpital de l'Archet, Centre Hospitalier Universitaire de Nice, Nice, France; Université Côte d'Azur, Nice, France; U1065, Centre Méditerranéen de Médecine Moléculaire, C3M, Virulence Microbienne et Signalisation Inflammatoire, INSERM, Nice</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Nice</settlement></placeName></affiliation></author><author><name sortKey="Giordanengo, Valerie" sort="Giordanengo, Valerie" uniqKey="Giordanengo V" first="Valérie" last="Giordanengo">Valérie Giordanengo</name><affiliation wicri:level="3"><nlm:affiliation>Department of Virology, Biological and Pathological Center, Centre Hospitalier Universitaire de Nice, 06200 Nice, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Virology, Biological and Pathological Center, Centre Hospitalier Universitaire de Nice, 06200 Nice</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Nice</settlement></placeName></affiliation></author><author><name sortKey="Vieira, Vera Esteves" sort="Vieira, Vera Esteves" uniqKey="Vieira V" first="Vera Esteves" last="Vieira">Vera Esteves Vieira</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Tissot Dupont, Herve" sort="Tissot Dupont, Herve" uniqKey="Tissot Dupont H" first="Hervé" last="Tissot Dupont">Hervé Tissot Dupont</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Honore, Stephane" sort="Honore, Stephane" uniqKey="Honore S" first="Stéphane" last="Honoré">Stéphane Honoré</name><affiliation wicri:level="4"><nlm:affiliation>Service Pharmacie, Hôpital Timone, AP-HM, Marseille, France; Laboratoire de Pharmacie Clinique, Aix Marseille Université, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service Pharmacie, Hôpital Timone, AP-HM, Marseille, France; Laboratoire de Pharmacie Clinique, Aix Marseille Université, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Colson, Philippe" sort="Colson, Philippe" uniqKey="Colson P" first="Philippe" last="Colson">Philippe Colson</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Chabriere, Eric" sort="Chabriere, Eric" uniqKey="Chabriere E" first="Eric" last="Chabrière">Eric Chabrière</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="La Scola, Bernard" sort="La Scola, Bernard" uniqKey="La Scola B" first="Bernard" last="La Scola">Bernard La Scola</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Rolain, Jean Marc" sort="Rolain, Jean Marc" uniqKey="Rolain J" first="Jean-Marc" last="Rolain">Jean-Marc Rolain</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Brouqui, Philippe" sort="Brouqui, Philippe" uniqKey="Brouqui P" first="Philippe" last="Brouqui">Philippe Brouqui</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Raoult, Didier" sort="Raoult, Didier" uniqKey="Raoult D" first="Didier" last="Raoult">Didier Raoult</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France. Electronic address: Didier.raoult@gmail.com.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32205204</idno><idno type="pmid">32205204</idno><idno type="doi">10.1016/j.ijantimicag.2020.105949</idno><idno type="pmc">PMC7102549</idno><idno type="wicri:Area/Main/Corpus">001848</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">001848</idno><idno type="wicri:Area/Main/Curation">001848</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">001848</idno><idno type="wicri:Area/Main/Exploration">001848</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial.</title><author><name sortKey="Gautret, Philippe" sort="Gautret, Philippe" uniqKey="Gautret P" first="Philippe" last="Gautret">Philippe Gautret</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Lagier, Jean Christophe" sort="Lagier, Jean Christophe" uniqKey="Lagier J" first="Jean-Christophe" last="Lagier">Jean-Christophe Lagier</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Parola, Philippe" sort="Parola, Philippe" uniqKey="Parola P" first="Philippe" last="Parola">Philippe Parola</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Hoang, Van Thuan" sort="Hoang, Van Thuan" uniqKey="Hoang V" first="Van Thuan" last="Hoang">Van Thuan Hoang</name><affiliation wicri:level="1"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France; Thai Binh University of Medicine and Pharmacy, Thai Binh, Viet Nam.</nlm:affiliation><country xml:lang="fr">Viêt Nam</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France; Thai Binh University of Medicine and Pharmacy, Thai Binh</wicri:regionArea><wicri:noRegion>Thai Binh</wicri:noRegion></affiliation></author><author><name sortKey="Meddeb, Line" sort="Meddeb, Line" uniqKey="Meddeb L" first="Line" last="Meddeb">Line Meddeb</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Mailhe, Morgane" sort="Mailhe, Morgane" uniqKey="Mailhe M" first="Morgane" last="Mailhe">Morgane Mailhe</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Doudier, Barbara" sort="Doudier, Barbara" uniqKey="Doudier B" first="Barbara" last="Doudier">Barbara Doudier</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Courjon, Johan" sort="Courjon, Johan" uniqKey="Courjon J" first="Johan" last="Courjon">Johan Courjon</name><affiliation wicri:level="3"><nlm:affiliation>Infectiologie, Hôpital de l'Archet, Centre Hospitalier Universitaire de Nice, Nice, France; Université Côte d'Azur, Nice, France; U1065, Centre Méditerranéen de Médecine Moléculaire, C3M, Virulence Microbienne et Signalisation Inflammatoire, INSERM, Nice, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Infectiologie, Hôpital de l'Archet, Centre Hospitalier Universitaire de Nice, Nice, France; Université Côte d'Azur, Nice, France; U1065, Centre Méditerranéen de Médecine Moléculaire, C3M, Virulence Microbienne et Signalisation Inflammatoire, INSERM, Nice</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Nice</settlement></placeName></affiliation></author><author><name sortKey="Giordanengo, Valerie" sort="Giordanengo, Valerie" uniqKey="Giordanengo V" first="Valérie" last="Giordanengo">Valérie Giordanengo</name><affiliation wicri:level="3"><nlm:affiliation>Department of Virology, Biological and Pathological Center, Centre Hospitalier Universitaire de Nice, 06200 Nice, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Virology, Biological and Pathological Center, Centre Hospitalier Universitaire de Nice, 06200 Nice</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Nice</settlement></placeName></affiliation></author><author><name sortKey="Vieira, Vera Esteves" sort="Vieira, Vera Esteves" uniqKey="Vieira V" first="Vera Esteves" last="Vieira">Vera Esteves Vieira</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Tissot Dupont, Herve" sort="Tissot Dupont, Herve" uniqKey="Tissot Dupont H" first="Hervé" last="Tissot Dupont">Hervé Tissot Dupont</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Honore, Stephane" sort="Honore, Stephane" uniqKey="Honore S" first="Stéphane" last="Honoré">Stéphane Honoré</name><affiliation wicri:level="4"><nlm:affiliation>Service Pharmacie, Hôpital Timone, AP-HM, Marseille, France; Laboratoire de Pharmacie Clinique, Aix Marseille Université, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service Pharmacie, Hôpital Timone, AP-HM, Marseille, France; Laboratoire de Pharmacie Clinique, Aix Marseille Université, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Colson, Philippe" sort="Colson, Philippe" uniqKey="Colson P" first="Philippe" last="Colson">Philippe Colson</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Chabriere, Eric" sort="Chabriere, Eric" uniqKey="Chabriere E" first="Eric" last="Chabrière">Eric Chabrière</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="La Scola, Bernard" sort="La Scola, Bernard" uniqKey="La Scola B" first="Bernard" last="La Scola">Bernard La Scola</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Rolain, Jean Marc" sort="Rolain, Jean Marc" uniqKey="Rolain J" first="Jean-Marc" last="Rolain">Jean-Marc Rolain</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Brouqui, Philippe" sort="Brouqui, Philippe" uniqKey="Brouqui P" first="Philippe" last="Brouqui">Philippe Brouqui</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Raoult, Didier" sort="Raoult, Didier" uniqKey="Raoult D" first="Didier" last="Raoult">Didier Raoult</name><affiliation wicri:level="3"><nlm:affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France. Electronic address: Didier.raoult@gmail.com.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author></analytic><series><title level="j">International journal of antimicrobial agents</title><idno type="eISSN">1872-7913</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Azithromycin (administration & dosage)</term><term>Betacoronavirus (MeSH)</term><term>Coronavirus Infections (drug therapy)</term><term>Drug Therapy, Combination (MeSH)</term><term>Female (MeSH)</term><term>Humans (MeSH)</term><term>Hydroxychloroquine (administration & dosage)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Pandemics (MeSH)</term><term>Pneumonia, Viral (drug therapy)</term><term>Polymerase Chain Reaction (MeSH)</term><term>Viral Load (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Association de médicaments (MeSH)</term><term>Azithromycine (administration et posologie)</term><term>Betacoronavirus (MeSH)</term><term>Charge virale (MeSH)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Hydroxychloroquine (administration et posologie)</term><term>Infections à coronavirus (traitement médicamenteux)</term><term>Mâle (MeSH)</term><term>Pandémies (MeSH)</term><term>Pneumopathie virale (traitement médicamenteux)</term><term>Réaction de polymérisation en chaîne (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Azithromycin</term><term>Hydroxychloroquine</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Azithromycine</term><term>Hydroxychloroquine</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Betacoronavirus</term><term>Drug Therapy, Combination</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Pandemics</term><term>Polymerase Chain Reaction</term><term>Viral Load</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Association de médicaments</term><term>Betacoronavirus</term><term>Charge virale</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Pandémies</term><term>Réaction de polymérisation en chaîne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Chloroquine and hydroxychloroquine have been found to be efficient on SARS-CoV-2, and reported to be efficient in Chinese COV-19 patients. We evaluate the effect of hydroxychloroquine on respiratory viral loads.</p></div><div type="abstract" xml:lang="en"><p><b>PATIENTS AND METHODS</b></p><p>French Confirmed COVID-19 patients were included in a single arm protocol from early March to March 16</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Six patients were asymptomatic, 22 had upper respiratory tract infection symptoms and eight had lower respiratory tract infection symptoms. Twenty cases were treated in this study and showed a significant reduction of the viral carriage at D6-post inclusion compared to controls, and much lower average carrying duration than reported in the litterature for untreated patients. Azithromycin added to hydroxychloroquine was significantly more efficient for virus elimination.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>Despite its small sample size, our survey shows that hydroxychloroquine treatment is significantly associated with viral load reduction/disappearance in COVID-19 patients and its effect is reinforced by azithromycin.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32205204</PMID><DateCompleted><Year>2020</Year><Month>08</Month><Day>04</Day></DateCompleted><DateRevised><Year>2020</Year><Month>08</Month><Day>04</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1872-7913</ISSN><JournalIssue CitedMedium="Internet"><Volume>56</Volume><Issue>1</Issue><PubDate><Year>2020</Year><Month>Jul</Month></PubDate></JournalIssue><Title>International journal of antimicrobial agents</Title><ISOAbbreviation>Int. J. Antimicrob. Agents</ISOAbbreviation></Journal><ArticleTitle>Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial.</ArticleTitle><Pagination><MedlinePgn>105949</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0924-8579(20)30099-6</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.ijantimicag.2020.105949</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Chloroquine and hydroxychloroquine have been found to be efficient on SARS-CoV-2, and reported to be efficient in Chinese COV-19 patients. We evaluate the effect of hydroxychloroquine on respiratory viral loads.</AbstractText><AbstractText Label="PATIENTS AND METHODS" NlmCategory="METHODS">French Confirmed COVID-19 patients were included in a single arm protocol from early March to March 16<sup>th</sup>, to receive 600mg of hydroxychloroquine daily and their viral load in nasopharyngeal swabs was tested daily in a hospital setting. Depending on their clinical presentation, azithromycin was added to the treatment. Untreated patients from another center and cases refusing the protocol were included as negative controls. Presence and absence of virus at Day6-post inclusion was considered the end point.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Six patients were asymptomatic, 22 had upper respiratory tract infection symptoms and eight had lower respiratory tract infection symptoms. Twenty cases were treated in this study and showed a significant reduction of the viral carriage at D6-post inclusion compared to controls, and much lower average carrying duration than reported in the litterature for untreated patients. Azithromycin added to hydroxychloroquine was significantly more efficient for virus elimination.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Despite its small sample size, our survey shows that hydroxychloroquine treatment is significantly associated with viral load reduction/disappearance in COVID-19 patients and its effect is reinforced by azithromycin.</AbstractText><CopyrightInformation>Copyright © 2020. Published by Elsevier B.V.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gautret</LastName><ForeName>Philippe</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lagier</LastName><ForeName>Jean-Christophe</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Parola</LastName><ForeName>Philippe</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hoang</LastName><ForeName>Van Thuan</ForeName><Initials>VT</Initials><AffiliationInfo><Affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France; Thai Binh University of Medicine and Pharmacy, Thai Binh, Viet Nam.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Meddeb</LastName><ForeName>Line</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>IHU-Méditerranée Infection, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mailhe</LastName><ForeName>Morgane</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>IHU-Méditerranée Infection, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Doudier</LastName><ForeName>Barbara</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>IHU-Méditerranée Infection, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Courjon</LastName><ForeName>Johan</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Infectiologie, Hôpital de l'Archet, Centre Hospitalier Universitaire de Nice, Nice, France; Université Côte d'Azur, Nice, France; U1065, Centre Méditerranéen de Médecine Moléculaire, C3M, Virulence Microbienne et Signalisation Inflammatoire, INSERM, Nice, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Giordanengo</LastName><ForeName>Valérie</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Department of Virology, Biological and Pathological Center, Centre Hospitalier Universitaire de Nice, 06200 Nice, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vieira</LastName><ForeName>Vera Esteves</ForeName><Initials>VE</Initials><AffiliationInfo><Affiliation>IHU-Méditerranée Infection, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tissot Dupont</LastName><ForeName>Hervé</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Honoré</LastName><ForeName>Stéphane</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Service Pharmacie, Hôpital Timone, AP-HM, Marseille, France; Laboratoire de Pharmacie Clinique, Aix Marseille Université, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Colson</LastName><ForeName>Philippe</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chabrière</LastName><ForeName>Eric</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>La Scola</LastName><ForeName>Bernard</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rolain</LastName><ForeName>Jean-Marc</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brouqui</LastName><ForeName>Philippe</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Raoult</LastName><ForeName>Didier</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France. Electronic address: Didier.raoult@gmail.com.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016430">Clinical Trial</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>03</Month><Day>20</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Int J Antimicrob Agents</MedlineTA><NlmUniqueID>9111860</NlmUniqueID><ISSNLinking>0924-8579</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>4QWG6N8QKH</RegistryNumber><NameOfSubstance UI="D006886">Hydroxychloroquine</NameOfSubstance></Chemical><Chemical><RegistryNumber>83905-01-5</RegistryNumber><NameOfSubstance UI="D017963">Azithromycin</NameOfSubstance></Chemical></ChemicalList><SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName><SupplMeshName Type="Protocol" UI="C000705127">COVID-19 drug treatment</SupplMeshName><SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Ann Rheum Dis. 2020 Jun;79(6):e60</RefSource><PMID Version="1">32295788</PMID></CommentsCorrections><CommentsCorrections RefType="CommentIn"><RefSource>Oncologist. 2020 Jun;25(6):455-457</RefSource><PMID Version="1">32304334</PMID></CommentsCorrections><CommentsCorrections RefType="CommentIn"><RefSource>Eur J Intern Med. 2020 Jul;77:139-140</RefSource><PMID Version="1">32414641</PMID></CommentsCorrections><CommentsCorrections RefType="CommentIn"><RefSource>J Neurol Sci. 2020 Aug 15;415:116972</RefSource><PMID Version="1">32534369</PMID></CommentsCorrections><CommentsCorrections RefType="CommentIn"><RefSource>J Glob Antimicrob Resist. 2020 Sep;22:680-684</RefSource><PMID 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MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017963" MajorTopicYN="N">Azithromycin</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="Y">Betacoronavirus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004359" MajorTopicYN="N">Drug Therapy, Combination</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006886" MajorTopicYN="N">Hydroxychloroquine</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & 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last="Hoang">Van Thuan Hoang</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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